Search results for "model [interaction]"

Existence for shape optimization problems in arbitrary dimension

2002

We discuss some existence results for optimal design problems governed by second order elliptic equations with the homogeneous Neumann boundary conditions or with the interior transmission conditions. We show that our continuity hypotheses for the unknown boundaries yield the compactness of the associated characteristic functions, which, in turn, guarantees convergence of any minimizing sequences for the first problem. In the second case, weaker assumptions of measurability type are shown to be sufficient for the existence of the optimal material distribution. We impose no restriction on the dimension of the underlying Euclidean space.

Traffic simulation models calibration using speed–density relationship: An automated procedure based on genetic algorithm

2016

Calibration of traffic models.Calibration as optimization problem.Use of genetic algorithm. This paper presents the first results of a research which applied a genetic algorithm to calibrate a microscopic traffic simulation model based on speed-density relationships. A large set of traffic data collected from the A22 Freeway, Italy, was used and a comparison was performed between the field measurements and the simulation outputs obtained for a test freeway segment by using the Aimsun microscopic simulator.The calibration was formulated as an optimization problem to be solved based on a genetic algorithm; the objective function was defined in order to minimize the differences between the sim…

The Responsibility of Professional Football Clubs under the Organizational Model Rules

2013

Nonsense-mediated mRNA decay controls the changes in yeast ribosomal protein pre-mRNAs levels upon osmotic stress.

2013

The expression of ribosomal protein (RP) genes requires a substantial part of cellular transcription, processing and translation resources. Thus, the RP expression must be tightly regulated in response to conditions that compromise cell survival. In Saccharomyces cerevisiae cells, regulation of the RP gene expression at the transcriptional, mature mRNA stability and translational levels during the response to osmotic stress has been reported. Reprogramming global protein synthesis upon osmotic shock includes the movement of ribosomes from RP transcripts to stress-induced mRNAs. Using tiling arrays, we show that osmotic stress yields a drop in the levels of RP pre-mRNAs in S. cerevisiae cell…

Study on difficulties and misconceptions with modern type systems

2014

Functional programming is often presented as an advantageous programming paradigm by its advocates, but many students and teachers consider it to be hard to learn. One particular hurdle in learning functional programming is mastering the modern type systems employed in these languages. In this article, we identify student difficulties with means of multiple choice questions embedded into the on-line materials of an introductory functional programming course. The most prevalent misconceptions were confusing with parametric polymorphism with subtyping, the assigning too much meaning to variables names, and confounding general language patterns with special cases.

Drosophila Models of Parkinson's Disease: Discovering Relevant Pathways and Novel Therapeutic Strategies

2010

Parkinson's disease (PD) is the second most common neurodegenerative disorder and is mainly characterized by the selective and progressive loss of dopaminergic neurons, accompanied by locomotor defects. Although most PD cases are sporadic, several genes are associated with rare familial forms of the disease. Analyses of their function have provided important insights into the disease process, demonstrating that three types of cellular defects are mainly involved in the formation and/or progression of PD: abnormal protein aggregation, oxidative damage, and mitochondrial dysfunction. These studies have been mainly performed in PD models created in mice, fruit flies, and worms. Among them, Dro…

Mappings ofBMO-distortion and beltrami-type operators

2002

EFFECTIVE FINITE-DIFFERENCE METHODS FOR THE SOLUTIONS OF FILTRATION PROBLEMS IN MULTILAYER DOMAINS

1997

In papers [1,2] there were consider different assumptions for averaging methods along the vertical coordinate.These methods were applied for the mathematical simulation of the mass transfer process in multilayered underground systems. A specific feature of these problems is that it is necessity to solve the 3‐D initial‐boundary‐value problems for parabolic type partial differential equations of second order with piece‐wise parameters in multilayer domain.Therefore here an effective finite‐difference method for solving a problem of the above type is developed.This method may be considered as a generalization of the method of finite volumes [3] for the layered systems. In the case of constant…

Superharmonic functions are locally renormalized solutions

2011

Abstract We show that different notions of solutions to measure data problems involving p-Laplace type operators and nonnegative source measures are locally essentially equivalent. As an application we characterize singular solutions of multidimensional Riccati type partial differential equations.

Test of Lorentz and CPT violation with short baseline neutrino oscillation excesses

2011

The sidereal time dependence of MiniBooNE ν[subscript e] and ν[over-bar][subscript e] appearance data is analyzed to search for evidence of Lorentz and CPT violation. An unbinned Kolmogorov–Smirnov (K–S) test shows both the ν[subscript e] and ν[over-bar][subscript e] appearance data are compatible with the null sidereal variation hypothesis to more than 5%. Using an unbinned likelihood fit with a Lorentz-violating oscillation model derived from the Standard Model Extension (SME) to describe any excess events over background, we find that the ν[subscript e] appearance data prefer a sidereal time-independent solution, and the ν[over-bar][subscript e] appearance data slightly prefer a sidereal…